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Overall, this review should be viewed as hypothesis-generating, mapping candidate pathways and highlighting priorities for well-designed intervention studies to test these mechanisms and strengthen causal inference

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What Has Happened So Far Phase 1 (2019-2022) The Lancet in 2022, demonstrating that the triple agonist mechanism (GIP, GLP-1, and glucagon receptors) was tolerable in humans and showing promising early weight loss signals

Conclusion As a starting point to inform deeper investigations into real-world variation and patient profiles for responsiveness to therapies, our research bridges the gap between clinical trials and GLP-1 use in the real world, where a broader, more diverse population is using GLP-1s in a variety of settings and personal contexts