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According to the 2018 ESMO guidelines, ID is defined by ferritin (FTN) levels below 100 g/L (absolute iron deficiency, AID) or FTN levels 100 g/L with a transferrin saturation (TSAT) under 20% (functional iron deficiency, FID) (6, 7)

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PMCID: PMC7108996 Andersen NB, Malmlf K, Johansen PB, Andreassen TT, rtoft G, Oxlund H

The high failure rates of experimental drugs in late-stage clinical trials highlight a disconnect between preclinical findings and human studies, largely due to inadequate disease models that fail to capture the full complexity of human AD pathology (Blaikie et al., 2022)