Por otro lado, los frmacos de accin prolongada, permiten un mayor control de la glucemia basal, como la exenatida de liberacin prolongada, liraglutida, dulaglutida, albiglutida y por ltimo semaglutida, aprobada recientemente por la FDA 56 .Adems, se ha demostrado que los GLP1-RA disminuyen el riesgo de eventos cardiovasculares al influir positivamente en factores de riesgo como obesidad, presin arterial y perfil lipdico 15
Dehydration from gastrointestinal side effects may also play a role
Instruct patients to inform healthcare providers prior to any planned surgeries or procedures if they are taking Saxenda Adverse Reactions The most common adverse reactions, reported in 5% are nausea, diarrhea, constipation, vomiting, injection site reactions, headache, hypoglycemia, dyspepsia, fatigue, dizziness, abdominal pain, increased lipase, upper abdominal pain, pyrexia, and gastroenteritis Drug Interactions Saxenda causes a delay of gastric emptying and has the potential to impact the absorption of concomitantly administered oral medications
Hydroxocobalamin, the form most commonly used in the UK, may cause: Injection site reactions (pain, redness, or swelling) Temporary reddish discolouration of urine Rarely, hypersensitivity reactions Very rarely, hypokalaemia in severely deficient patients when treatment is initiated (potassium levels should be monitored in severe deficiency) B12 injections are considered very safe, with no upper tolerable limit established, as excess B12 is excreted in urine
