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TETs, comprising TET1, TET2, and TET3, catalyze the oxidative conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxycytosin (5caC) in an Fe (II)/a-ketoglutarate-dependent manner

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Tirzepatide mimics or enhances the effects of two amino acid peptides: GLP-1 (glucagon-like peptide-1) and GIP (gastric inhibitory polypeptide)

Selectively engaging -arrestins at the angiotensin II type 1 receptor reduces blood pressure and increases cardiac performance