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Timing and lifestyle factors Heart rate naturally fluctuates throughout the day, and certain factors can amplify the effects of retatrutide on cardiac rate: Caffeine is an adenosine receptor antagonist that independently increases heart rate

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GLP-1 agonists appear to work through similar reward pathway modulation via different receptors

Dietary adjustments are often the first line of self-management: Eat smaller, more frequent meals rather than large portions Avoid high-fat, greasy, or heavily spiced foods, which can exacerbate loose stools Reduce intake of foods known to cause wind, such as beans, cruciferous vegetables, and carbonated drinks If constipation is the predominant symptom, increase soluble fibre gradually sudden large increases in fibre can worsen bloating and discomfort Stay well hydrated, particularly if experiencing diarrhoea, to prevent dehydration Timing and lifestyle considerations can also make a meaningful difference