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Description

DSIP has a plasma half-life of only a few minutes due to rapid degradation by blood peptidasesyet behavioral effects in sleep normalization and HPA axis modulation persist for days to weeks after a single administration

doi: 10.1128/MCB.00099-20

Psychiatry 10 (1), 238

A refined definition of astrocyte reactivity includes four key features: (1) cellular, molecular and functional changes in response to CNS insults, (2) graded responses depending on insult severity, (3) context-dependent reactions influenced by intra- and intercellular signaling and (4) beneficial or detrimental effects on surrounding cells 35