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But with more people taking GLP-1 injectable drugs, there are more concerns about potentially serious side effects
The agonist NLY01 exemplifies this mechanism by crossing the blood-brain barrier to directly target microglial GLP-1Rs, in addition to blocking dopaminergic neuron loss in Parkinson's models through preventing microglia activation and generation of neurotoxic reactive astrocytes [47] and potentially PI3K/AKT-mediated survival pathways [24] (Fig
doi: 10.1007/s10552-009-9385-0 181 HoltSKKwonEMPetersUOstranderEAStanfordJL