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, e.g., morning headaches due to increased renin production Heart valve defects (commonly mitral valve prolapse) Pericardial effusion Left ventricular hypertrophy Coronary artery aneurysm and aortic aneurysm Neurological: intracranial saccular aneurysm (in 8% of patients with ADPKD) [1] Higher risk if positive ADPKD family history Aneurysm rupture: clinical features of SAH Other manifestations Bronchiectasis Cysts in the spleen, ovaries, or seminal vesicles Hypertension, hematuria, and UTIs often precede kidney function decline