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The Triple Agonist Mechanism and Weight Loss Huberman described retatrutide as a triple agonist of the GLP-1, glucagon, and GIP receptors, and noted that it is sometimes referred to as "GLP-3." He made a striking claim about the weight loss data: "In a phase three clinical trial in humans, it caused up to one-third loss of body weight

Because GLP-1 plays a role in appetite and calorie intake, liraglutide belongs to a peptide conversation that is very different from peptides discussed for growth hormone signaling, recovery routines, or other goals

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I understand that that exists with, you know SSRIs and things like that, but its even wilder to think that little voice that tells you this one time is not gonna hurt, that rationalization that you do to yourself, that feels like you, but in fact, it can be just a chemical reaction inside your brain