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When we produce more GLP-1, it increases our sensitivity to leptin, our satiety hormone
Furthermore, recent studies show the benefits of tirzepatide in people with metabolic dysfunctionassociated steatohepatitis (MASH) [5], in people with heart failure with preserved ejection fraction (HFpEF) and obesity [6], and in people with T2D with established atherosclerotic cardiovascular disease according to a recent press release [7]
The gut microbiota-brain axis in neurological disorder
It was barely noticeable in Phase 2 but appeared in up to 20.9% of patients on the highest dose in Phase 3
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![PDF] Oral semaglutide versus subcutaneous liraglutide and placebo in type 2 diabetes (PIONEER 4): a randomised, double-blind, phase 3a trial](https://figures.semanticscholar.org/e8287c4738beb6498b0b672a9e21849ac413152a/7-Figure2-1.png)
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