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Because the drug remains in clinical development, long-term reproductive data are not yet available, and fertility outcomes were not a primary endpoint in the Phase 2 trials conducted to date

This happens partly because of weight loss but also because these medications reduce ectopic fat (unhealthy fat around organs) and decrease inflammation

Frias JP, Davies MJ, Rosenstock J, Perez Manghi FC, Fernandez Lando L, Bergman BK, Liu B, Cui X, Brown K, Investigators S-

Tirzepatide delivers substantially greater weight loss (20.9% vs 12.4%) through its dual GIP/GLP-1 mechanism and is FDA-approved with a large evidence base