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Decreased expression of survivin contributes to the sensitization of cancer cells to chemotherapy by IGF-IR inhibitors

Data sets were analyzed for outliers with Grubbs test using Graphpad Outlier Calculator and values were excluded if identified as outliers

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During the initial period, leukocyte-derived MMP-9 and brain-derived MMP-2 are involved, and later, MMP-3 and MMP-9, angiogenesis, and vasogenic edema may occur, which can destroy NVUs and exacerbate the destruction of the BBB [120, 121]