A cross-sectional study based on NHANES 2003-2004 data from 2,638 participants ages 40 years and over found that the risk of high blood pressure (hypertension), a major contributing factor for CVD, was 73% higher in individuals in the upper versus lowest quintile of serum selenium concentrations (150 g/L vs
Associations of Serum Magnesium With Insulin Resistance and Testosterone in Women With Polycystic Ovary Syndrome
The molecular pathogenesis of DCM involves interconnected mechanisms including inflammation, hyperglycemia, insulin resistance, fatty acid dysregulation, oxidative stress, mitochondrial dysfunction, and endothelial dysfunction ( Of particular significance, inflammation emerges during early-stage diabetes and acts as a key driver of DCM progression ( These core mechanisms act synergistically, inducing severe metabolic dysregulation characterized by lipid accumulation (lipotoxicity), progressive mitochondrial impairment, sustained oxidative stress, inflammatory activation, myocardial fibrosis, and enhanced apoptosis
Nondiabetic LETO (Long-Evans Tokushima Otsuka) rats fed the same standard diet were used as age-matched controls (nondiabetic group)
