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Serious but less common adverse effects include pancreatitis, gallbladder disease, acute kidney injury (particularly in the setting of dehydration from gastrointestinal symptoms), and hypoglycemia when used in combination with insulin or sulfonylureas

Side Effects: What to Expect Both pill and injection forms of GLP-1 medications can cause similar side effects, but there are some important differences in frequency and severity

Retatrutide is notable because it targets three hormone pathways rather than one or two

"Efficacy and Safety of Semaglutide Versus Dulaglutide as add-on to Metformin in Subjects With Type 2 Diabetes