More importantly, combined with drug-encapsulating silk fibroin NPs, cartilage-targeting WYRGRL peptide, and sustained-release soluble MNs, we designed and prepared the cartilage-targeting MNs/GLP-1RAs@NPs-WYRGRL which offers a novel and highly translatable strategy for precise, efficient, and low-side-effect therapy in the management of rheumatoid arthritis
Another therapeutic strategy for kidney or liver diseases is increasing NAD + production by inhibiting ACMSD in the de novo NAD + synthesis pathway 235,301
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