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Over decades of development in critical care medicine, effective early identification and therapeutic interventions, including early infection control, maintenance of hemodynamic stability and modulation of the host response, have successfully reduced mortality rates during the acute phase of sepsis, leading to an increase in the number of sepsis survivors (5-7)

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The present model corroborates previous findings of synapse-like remodeling around DRG somata in chronic pain and synaptic marker enrichment in human DRG neurons revealed through increased PSD95 and synaptophysin levels in the DRG (Sun et al

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