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Same empty-stomach rules apply

These medications mimic a natural hormone that helps regulate appetite, slow digestion, and support healthier blood sugar patterns

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This introduces clinical heterogeneity and considerably attenuates the practical interpretation of pooled estimates, given the well-established beneficial effects of GLP-1 RAs in reducing both HbA 1c and body weight, as opposed to the neutral effect of a placebo intervention [4,5,6]