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Frequently asked questions Early warning signs of B12 deficiency include unexplained fatigue, tingling or numbness in your hands and feet, difficulty concentrating, and mood changes

This condition is characterised by impaired glucose disposal and increased hepatic glucose production, as well as disruptions in sex hormone regulation

Furthermore, impaired GH secretion in these individuals is linked to a reduction in visceral fat and elevated ghrelin concentrations relative to the degree of obesity (110)

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