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By targeting all three receptors, retatrutide is designed to produce a more pronounced effect on body weight and blood glucose regulation, though whether this translates into superior long-term clinical outcomes remains to be confirmed in Phase 3 trials

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The most important caveat is that biotin can interfere with thyroid blood tests, causing falsely abnormal results

Subsequent subregion analyses showed that the ventral tegmental area as well as subregions of the amygdala displayed enhanced activity patterns after GLP-1MK-801 treatment (Extended Data Fig