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A42 levels and the A42/A40 ratio were reduced, but polymerization of A40 and A42 increased, along with enhanced resistance to proteolytic degradation by neprilysin (Nilsberth et al., 2001

These factors contribute to chronic illness and inflammation

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Stopping rules: Discontinue GHK-Cu if free copper exceeds 25 mcg/dL, 24-hour urine copper exceeds 100 mcg/day, ALT or AST rises to more than 3 times the patient's baseline value, or clinical signs of copper toxicity appear