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The intervention showed significant effects, with the EPA group experiencing fewer monthly migraine days, reduced usage of headache medication, and improvements in headache severity (VAS score), disability (MIDAS score), anxiety and depression (HADS score), and quality of life (MSQ score)

Quercetin exerts neuroprotective effects through the upregulation of p-Akt expression, downregulation of p-ASK1, p-JNK3, and cleaved caspase-3 expression, and inhibition of neuronal apoptosis (Pei et al., 2016)

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