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This multi-receptor interaction profile differentiates GLP-3R from earlier peptide constructs that primarily targeted single-pathway or dual-pathway receptor activity

In combination with the restored insulin sensitivity after RYGB surgery, the increased insulin in PBH may just have tipped the balance and induced extra inhibition of beta oxidation, and as consequence increased glycolysis leading to decreased plasma glucose

Med 65 , 11011109 (2013)

[3] Whilst Mounjaro itself does not directly cause B12 deficiency, the dietary changes and reduced food intake associated with its use could theoretically contribute to suboptimal nutrient intake