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For example, in this study, tirzepatide led to an average weight loss of 20.2% compared to 13.7% with semaglutide

academic.oup.com/jes/article/9/ Gut hormones like ghrelin ( hunger) & GLP-1/PYY ( hunger) signal to the hypothalamus' arcuate nucleus

Because these therapies include both GLP-1 and GIP receptor agonists, our weight loss medications can offer superior appetite suppression and metabolic benefits compared to GLP 1 alone