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Glucagon-Like Peptide-1 Receptor Agonist Dulaglutide Prevents Ox-LDL-Induced Adhesion of Monocytes to Human Endothelial Cells: An Implication in the Treatment of Atherosclerosis
Mechanistically, GLP-1 receptor agonists may exert vascular protective effects by suppressing inflammation, limiting oxidative stress, and modulating key enzymes involved in extracellular matrix remodeling ( Matrix metalloproteinases, particularly MMP-9, together with their endogenous inhibitors (TIMPs), play central roles in extracellular matrix turnover and structural vascular remodeling ( The reduction in CRP, a recognized marker of aortic stiffness, medial degeneration, and systemic inflammation, further supports the anti-inflammatory profile associated with GLP-1RA therapy
Counteraction of GLP-1 effect on gastric emptying by co-infusion with prokinetic drug erythromycin during a liquid test meal diminished GLP-1s ability to decrease postprandial hyperglycemia in patients with T2DM (153)
US$ 21.41
US$ 21.98
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US$ 21.38
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