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Poor sleep, poor nutrition, minimal exercise, and chronic stress have profound effects on the same markers that peptides address, and those effects are larger and more amenable to intervention than most peptide interventions

In AD, along with amyloid and tau phosphorylation, there is an associated increase in inflammation/glial activation, a decrease in synaptic function, an increase in astrocyte activation, and a state of insulin resistance

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Their effect on energy homeostasis is mediated by the hypothalamus and brainstem, and several studies have demonstrated alterations in neuropeptide signaling within the arcuate nucleus