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However, it is not a facelift

People see Ozempic's results, hear that retatrutide produced even larger reductions in trials, and assume combining them compounds the effect

The rationale for including glucagon receptor agonism is the mechanistically interesting part: glucagon signalling raises hepatic energy expenditure and promotes lipolysis but also raises circulating glucose on its own, so the two incretin arms are there to counterbalance that consequence while the thermogenic effect proceeds