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ERK1/2 Activation Extracellular signal-regulated kinases 1 and 2 trigger transcription factors c-Fos and c-Jun when activated by BPC-157

There is one small pilot study in humans (examining knee pain, where 7 of 12 participants reported sustained improvement beyond 6 months) and a 2025 safety study confirming BPC-157 was well tolerated in healthy adults

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