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And it has many social, commercial and environmental determinants, requiring action in many sectors not only in the clinic. These other determinants of obesity, such as a food environment rich in high sugar, fat, and salt foods, mean that the global overweight or obese population is expected to reach 60% by 2050

Since these drugs have emerged as compelling therapies for weight loss, the market for semaglutide has ultimately failed

The increase in GLP-1RA use going forward is expected to have fundamental impacts on broader consumer and commercial behavior

Persistent vomiting or diarrhoea can lead to dehydration, which in turn may increase the risk of acute kidney injury a class-relevant concern also noted in the Summary of Product Characteristics (SmPC) for approved GLP-1 receptor agonists such as semaglutide