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The release of vasoactive intestinal peptide (VIP) and acetylcholine (Ach) by submucosal neurons stimulates the enterocyte and Cl enters by co-transport with sodium and potassium through the basolateral Na + -K + -2Cl channel

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Consequently, it is also postulated that Sermorelin may retain the fundamental capability of GHRH, potentially stimulating the intermittent release of growth hormone by engaging GHRH receptors in the pituitary gland