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In order to qualify for the study patients had to be at least 18 years of age with a diagnosis of type 2 diabetes and treated for at least three months with diet and exercise and/or a stable regiment of metformin, as well as an HbA1c level of 7-10% and a body weight of 60-110 kg

Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future

Doses are then adjusted based on fasting blood glucose readings, typically every 3 to 4 days

Depletion of collagen content in the basal lamina of glomerular membrane and tubular epithelial cells indicates glomerular hyperpermeability and disturbance in the processes of renal handling (Abd-Elkareem et al., 2020