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Caffeine's phosphodiesterase (PDE) inhibition sustains elevated cyclic AMP (cAMP) levels in adipocyte tissue, prolonging the activation of hormone-sensitive lipase (HSL) and extending the fat release window beyond what hormonal lipolytic signals alone would maintain

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Furthermore, the study noted an apparent reduction in myeloperoxidase (MPO) activity, which is primarily found in neutrophils and is an enzyme involved in the model's response to inflammation