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However, oral semaglutide and other GLP-1 RA drugs act by increasing insulin secretion, inhibiting glucagon secretion that leads to reduced hepatic glucose production, correcting defects in the production of gastrointestinal incretins, and promoting an effect on the central nervous system that leads to appetite suppression and weight loss, which is reflected in increased muscle and liver sensitivity to insulin [67, 68]

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Clarke R, Sherliker P, Hin H, Molloy AM, Nexo E, Ueland PM, Emmens K, Scott JM, Evans JG