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Early on, the tissue is being actively re-signaled and needs the most consistent exposure, so activation is daily

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Individual variation : People may respond differently to supplements based on their underlying health status, though controlled studies examining formulation-specific effects on anxiety are lacking

Methods Trial design and participants This phase 3, randomized, double-blind, placebo-controlled study was conducted at 41 sites across five countries (Canada, Italy, Hungary, Spain and the United States), as described in a previous publication 8 and listed in the Supplementary information