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Ipamorelin: Selective GHSR-1a Agonism Ipamorelin is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) that binds the ghrelin receptor, formally known as the growth hormone secretagogue receptor type 1a (GHSR-1a) [1]

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3 Management and treatment of osteoarthritis 3.1 Non-pharmacological management Non-pharmacological interventions form the foundation of contemporary OA management and are universally recommended as first-line therapy across all disease stages and phenotypes