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Systemic drug therapy (e.g., with immune checkpoint inhibitors, BRAF inhibitors, and MEK inhibitors) or radiation therapy may be indicated in patients with metastatic or unresectable disease

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Additionally, the long noncoding RNA LINC00578 binds to UBE2K, disrupting its interaction with SLC7A11 and inhibiting the ubiquitination of SLC7A11, thus promoting PDAC cell invasiveness and resistance to ferroptosis [65]

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