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Research applications for MT-1 span photoprotection biology, melanogenesis studies, wound healing research (MC1R is expressed on keratinocytes and fibroblasts), anti-inflammatory research, and comparative melanocortin receptor studies where MC1R-specific activity must be isolated from MC4R-mediated CNS effects

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A particular emphasis has been on the role of the incretin hormones of the gut (GLP-1 and GIP)