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These early studies confirmed the once-weekly dosing feasibility and identified the gastrointestinal side effectsprimarily nausea, vomiting, and diarrheathat would become characteristic of GLP-1 receptor agonist therapy

According to current diagnostic criteria, POTS is defined by a sustained heart rate increase of 30 beats per minute or more (or to above 120 beats per minute) within 10 minutes of standing, in the absence of orthostatic hypotension (a drop in blood pressure of 20/10 mmHg)

This extended half-life is partly due to its high albumin binding

"As with all observational studies, we need to interpret this study with a grain of salt," Dr