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89,90 Although all causes and contributors of obesity are not within an individuals control, structured lifestyle modification programs can be effective and feasible to help achieve a 5-10% weight reduction and maintain a healthy body weight for many people

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The natural flavonoid fisetin induces apoptosis in HCT-116 colon cancer cells by inhibiting HSF1 binding to the HSP70 and BAG3 promoters, thereby suppressing the heat shock response and promoting cell death