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This epigenetic reprogramming is partly linked with other ITC effects: HDAC inhibition by SFN has been associated with the suppression of phase I carcinogen-activating enzymes and the concurrent induction of phase II detoxifiers (118)

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Its importance to human health was first recognized in the early 1960s, when Iranian patients presenting severe anemia, growth retardation, hypogonadism, skin lesions and lethargy were found to be zinc-deficient 1,2

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