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Red flags warranting immediate provider contact: uncontrolled blood sugar despite semaglutide escalation, rapid or unintended weight loss (suggesting prednisone taper success that may require semaglutide reduction), severe nausea, persistent abdominal pain, signs of infection (prednisone immunosuppression), or mood changes

Reason(s) behind the rise of compounded semaglutide: While compounding drugs isnt a new practice, due to the soaring demand for these weight loss drugs, its now a mainstream phenomenon

19 The Trial to Evaluate Cardiovascular and Other Long-term Outcomes with Semaglutide in Subjects with Type 2 Diabetes (SUSTAIN) trials with semaglutide also demonstrated a reduction in HbA1c levels, body weight, and cardiovascular events in individuals with type 2 diabetes

Semaglutide, under the brand name Wegovy, is approved as an adjunct for weight loss along with a reduced-calorie diet and increased physical activity