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Skin and Extracellular Matrix Research Epithalon has been studied in connective tissue and skin-related models focusing on fibroblast function and extracellular matrix integrity: Rodent studies indicate that Epithalon may increase fibroblast activation and proliferation parameters, with reported relative increases in fibroblast activity in certain skin models

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Similarly, the genetic background of the sex-linked dwarf (SLD) chickens, which are caused by GHR gene mutations, also allows this strain to become a model system to understand the roles of GHR in vivo (Luo et al., 2016)