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IFN-, produced by NK cells and T CD4 + lymphocytes, play a crucial role in macrophage activation, differentiation, and induction of proinflammatory expression such as iNOS (Duque et al., 2014

doi: 10.1016/j.cct.2015.09.002 21 GuyattGHOxmanADKunzRWoodcockJBrozekJHelfandMet al

Together, these observations demonstrate marked variability in the ability of short-term metformin to lower rates of gluconeogenesis under basal or clamp conditions in youth and adults with modest hyperglycaemia