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PlexusDx recommends baseline metabolic screening before starting any GLP-1 therapy to identify contraindications and optimize treatment safety and effectiveness

Developing a discontinuation plan should include establishing baseline measurements (weight, waist circumference, metabolic parameters), setting realistic expectations about weight maintenance challenges, creating a detailed lifestyle modification plan with specific, measurable goals, scheduling regular follow-up appointments (initially monthly, then quarterly), identifying triggers for earlier intervention if weight regain occurs, and discussing alternative pharmacological options if needed

Patients exploring currently available, provider-prescribed options such as Mounjaro or Zepbound may recognize a similar philosophy, since these treatments are also adjusted gradually under supervision rather than started at a high level immediately