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For patients who need both Toujeo specifically (the U-300 concentration) and a GLP-1 agonist, separate injections are currently the only option, as there is no combination product using the U-300 concentration

9 One meta-analysis synthesizing on the order of a dozen RCTs and several hundred participants found consistent improvement in HOMA-IR and anthropometric measures with GLP-1 receptor agonists relative to controls

Daily Microdose Titration (Maximum Stability) The flattest concentration curve with P/T ratio of ~1.2

Medications known as GLP-1 agonists, including exenatide, liraglutide, and semaglutide, activate the GLP1R, effectively lowering blood sugar levels and facilitating weight loss in individuals with type 2 diabetes