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Currently, the initial test for vitamin B 12 deficiency is to assess serum vitamin B 12 levels, and only when there is low normal vitamin B 12 level, metabolite assay is most often suggested.11 12 However, the consensus for vitamin B 12 threshold levels for ordering the additional tests has not yet been reached

observed in Nature Medicine , NNMT inhibition in adipose tissue produced favorable body composition changes without negatively impacting muscle mass (Kraus et al., Nature Medicine )