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We found that 2A -adrenergic receptor activation by DA or NE results in G i1 recruitment to the receptor, with NE showing higher potency (EC 50 = 520 1.4 nM) and efficacy compared to DA (EC 50 = 2.1 0.002 M

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Prof Alexander Miras, an obesity expert at Ulster University who was not involved in the work, described the findings as very important, noting that while GLP-1s had been associated with improved functionality meaning it was easier to carry out everyday activities they had also been associated with a loss in muscle mass and strength