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A likely contributor to this iron accumulation is the reduction in ferroportin expression that inhibits iron export from DSCs

Furthermore, metformin diminishes the presence of Bacteroides fragilis , a bacterium that suppresses bile salt hydrolase activity, leading to a rise in secondary bile acids like GUDCA

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Genetic Polymorphisms in the Catechol Estrogen Metabolism Pathway and Breast Cancer Risk. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, vol