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It upregulates IGF-1 expression in certain regions of the brain, such as the hypothalamus, cerebellum, and hippocampus

The temporal relationship between diabetes and cancer: a population-based study

Plamboeck A, Veedfald S, Deacon CF, Hartmann B, Wettergren A, Svendsen LB et al

Along with this hypothesis, PPIs have been shown to increase bacterial species that are normally found in the mouth, such as Rothia dentocariosa, Rothia mucilaginosa, the genera Actinomyces, and the family micrococcaceae in the gut microbiota as well, which would correlate with the alkalinity of gastric acid as the cause of gut dysbiosis (Imhann et al