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to improve blood sugar levels in adults with type 2 diabetes mellitus who have severe kidney problems (if their eGFR is less than 30 mL/min/1.73 m2)

Back Holst, JJ, rskov,C, Schwartz, TW, et al (29 Aug 1986) 'Proglucagon 78-107, a potent insulinotropic hormone from lower smaller intestine', Diabetologia:Abstracts , 511A-610A.Back Holst, JJ, rskov, C, Vagn Nielsen, O, Schwartz, TW (1987) 'Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut', FEBS letters , 211/2

78 These changes stabilize its structure, prevent protein degradation of the molecule in the circulation, and increase the circulation time enough to ensure once-daily injection (compared with exenatide, which is injected two or three times daily)