They can be released by most cell types, such as epithelial cells, cancer cells, neural cells, immune cells, embryonic cells, endothelial cells, and MSCs (Mashouri et al., 2019)
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ALS can be phenotypically classified into either limb onset (LO) cases with upper and lower motor neurons being affected, accounting for 70% of the cases, or Bulbar onset (25%) in which speech and swallowing issues first arise that are followed by later stage limb weakness (Zarei et al., 2015)